ARTIKEL REVIEW: PENGARUH PERLAKUAN PADA PATI SEBAGAI SUPERDISINTEGRAN TERHADAP WAKTU HANCUR FAST DISINTEGRATING TABLET

Gina Novita, Dadih Supriadi, Fenti Fatmawati

Abstract


Pati banyak digunakan dalam formulasi Fast Disintegratating Tablet (FDT) sebagai superdisintegran karena biodegradabilitas dan biokompatibilitasnya, namun beberapa kekurangannya seperti kompresibilitas, sifat alir dan daya serap terhadap air yang rendah dapat membatasi aplikasinya seperti mempengaruhi keseragaman bobot, kesulitan dalam mengempa tablet dan waktu hancur tablet lebih lama. Berbagai modifikasi pati baik secara fisika, kimia, enzimatis maupun kombinasi dilakukan untuk meningkatkan efektivitas penggunaan pati. Tujuan review jurnal ini untuk memberikan informasi mengenai pengaruh perlakuan pada pati dari berbagai sumber sebagai superdisitegran terhadap waktu hancur FDT. Review jurnal ini dilakukan dengan metode literatur review. Pengumpulan data dilakukan melalui elektronik database PubMed dan Google cendekia. Pati hasil modifikasi memiliki permukaan granula pati lebih berpori berdasarkan hasil SEM dibandingkan pati alami. FDT menggunakan superdisintegran pati hasil modifikasi memiliki waktu hancur lebih cepat (<1 menit) dibandingkan pati alami (2-3 menit). Komposisi pati yang digunakan dalam formulasi FDT dapat mempengaruhi waktu hancur tergantung dari sumber pati dan modifikasi pati yang dilakukan. Modifikasi pati secara kimia diantaranya mengkombinasikan pati xanthate dan CMC Na memiliki waktu hancur 12 detik, modifikasi pati beras ikatan silang karboksimetil dengan sodium silikat memiliki waktu hancur 16,83 detik dan modifikasi pati dengan konjugasi glycine memiliki waktu hancur 19 detik merupakan formula yang paling efektif digunakan sebagai superdisintegran dalam formulasi Fast Disintegrating Tablet. 


Full Text:

PDF

References


Bhowmik D, Chiranjib B, Chandira RM. Fast Dissolving Tablet_ An Overview _ Abstract. J Chem Pharm Res. 2009;1(1):163–77.

R. Pahwa, M. Piplani, P. C. Sharma, D. Kaushik and SN. Orally disintegrating tablets friendly to pediatrics and geriatrics. Arch Appl Sci Res. 2010;02(02):35–48.

ZHANG W, WANG Y, GAO X, GAO X, PENG S, ZHENG Y, et al. Optimization of Jiawei Qing’e Oral Fast Disintegrating Tablets Based on Response Surface-Central Composite Design. Optim Jiawei Qing’e Oral Fast Disintegrating Tablets Based Response Surface-Central Compos Des [Internet]. 2013;5(2):138–44. Available from: http://dx.doi.org/10.3969/j.issn.1674-6348.2013.02.011

Suryadevara V, Lankapalli SR, Danda LH, Pendyala V, Katta V. Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integr Med Res [Internet]. 2017;6(3):280–91. Available from: http://dx.doi.org/10.1016/j.imr.2017.04.001

Eryani MC, Wikarsa S, Soemirtapura YC. Formulasi dan Evaluasi Fast Disintegrating Tablet (FDT) Loratadin. Acta Pharm Indones. 2018;39(1 & 2):26–32.

Juneja P, Kaur B, Odeku OA, Singh I. Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets. J Drug Deliv. 2014;2014:1–13.

Sadeghi M, Hemmati S, Salehi R, Solhi M, Ghorbani M, Hamishehkar H. Leucine-grafted starch as a new superdisintegrant for the formulation of domperidone tablets. J Drug Deliv Sci Technol [Internet]. 2019;50(January):136–44. Available from: https://doi.org/10.1016/j.jddst.2019.01.021

Eraga SO, Nwajuobi VN, Iwuagwu MA. Super-disintegrant activity of acid-modified millet starch in diclofenac tablet formulations. J Sci Pract Pharm. 2017;4(1):161–8.

Singh A V., Nath LK, Guha M, Kumar R. Microwave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant. Pharmacol & Pharm. 2011;02(01):42–6.

Sadeghi M, Hemmati S, Hamishehkar H. Synthesis of a novel superdisintegrant by starch derivatization with polysuccinimide and its application for the development of ondansetron fast dissolving tablet. Drug Dev Ind Pharm. 2016;42(5):769–75.

Sharma D. Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders. ISRN Pharm. 2013;2013:1–8.

Zaki A, Anwa E, Surini S. Formulation of a fast-disintegrating tablet using maltodextrin DE 10-15 and pregelatinizated cassava starch as expedients. Int J Appl Pharm. 2017;9:71–3.

Bestari AN, Sulaiman TNS, Rohman A. Formulasi Orally Disintegration Tablet (ODT) Meloksikam dengan Variasi Komposisi Ac-Di-Sol dan Kollidon Cl® sebagai Bahan Penghancur. Maj Farm. 2016;12(2):453–65.

Monica E, Rollando R, Sitepu R, Nisah DRK, Irawati LN, Listio SDL. Formulation of fast disintegrating tablet paracetamol employing selected super-disintegrant. Int J Res Pharm Sci. 2020;11(3):4323–33.

Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Syst. 2004;21(6):433–75.

Kaur T, Gill B, Kumar S, Gupta GD. Mouth Dissolving Tablets: A Novel Approach To Drug Delivery. Int J Pharm Res [Internet]. 2011;3(1):1–7. Available from: http://www.ijcpr.org/Issues/Vol3Issue1/257.pdf

Shihora H, Panda S. Superdisintegrants , Utility in Dosage Forms : A Quick Review. J Pharm Sci Biosci Res. 2011;1(3):148–53.

Bala R, Khanna S, Pawar P. Polymers in fast disintegrating tablets - A review. Asian J Pharm Clin Res. 2012;5(2):8–14.

Huanbutta K, Sittikijyothin W. Development and characterization of seed gums from Tamarindus indica and Cassia fistula as disintegrating agent for fast disintegrating Thai cordial tablet. Asian J Pharm Sci [Internet]. 2017;12(4):370–7. Available from: http://dx.doi.org/10.1016/j.ajps.2017.02.004

Yadav ND, Pingale PL, Tatane SR. Available online through Comparative study on effect of natural and artificial superdisintegrants in the formulation of fast dissolving aspirin tablet. 2010;3(7).

Malviya R, Srivastava P, Bansal M, Sharma PK. Mango peel pectin as a superdisintegrating agent. J Sci Ind Res (India). 2010;69(9):688–90.

Sipos E, Oltean AR, Szabó ZI, Rédai EM, Nagy GD. Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets. Acta Pharm. 2017;67(2):237–46.

Kumar A, Saharan VA. Salbutamol Sülfatın Oral Dağılan Tabletlerinin Formülasyonu ve Değerlendirilmesi: Süper Dağıtıcıların Farklı Oranlarının Karşılaştırmalı Çalışması. Turkish J Pharm Sci. 2017;14(1):40–8.

Garcia MAVT, Garcia CF, Faraco AAG. Pharmaceutical and Biomedical Applications of Native and Modified Starch: A Review. Starch/Staerke. 2020;72(7-8):1–15.

Rowley J, Slack F. Conducting a literature review. Manag Res News. 2004;27(6):31–9.

Cahyono EA, Sutomo, Harsono A. Literatur Review: Panduan Penulisan dan Penyusunan. J Keperawatan. 2019;12.

El Halal SLM, Kringel DH, Zavareze E da R, Dias ARG. Methods for Extracting Cereal Starches from Different Sources: A Review. Starch/Staerke. 2019;71(11-12):1–14.

Irhami, Anwar C, Kemalawaty M. Physicochemical Properties of Sweet Potato Starches by Studying Their Varieties and Drying Temperatures. J Teknol Pertan. 2019;20(1):33–44.

Winarti, S., Purnomo Y. Olahan Biji Buah. Surabaya: Trubus Agrisarana.; 2006.

Syahraeni K. Karakterisasi Tepung Empat Varietas Pisang di Lembah Palu. J Agrisains. 2005;6(April):1–6.

A. Korma S. Chemically Modified Starch and Utilization in Food Stuffs. Int J Nutr Food Sci. 2016;5(4):264.

Venkatarao M, Vidyadhara S, Sandeep D. Formulation and evaluation of Atorvastatin fast dissolving tablets using Entada scandens seed starch as superdisintegrant. Asian J Pharm. 2018;12(3):170–81.

Martens BMJ, Gerrits WJJ, Bruininx EMAM, Schols HA. Amylopectin structure and crystallinity explains variation in digestion kinetics of starches across botanic sources in an in vitro pig model. J Anim Sci Biotechnol. 2018;9(1).

Wang LF, Pan SY, Hu H, Miao WH, Xu XY. Synthesis and properties of carboxymethyl kudzu root starch. Carbohydr Polym [Internet]. 2010;80(1):174–9. Available from: http://dx.doi.org/10.1016/j.carbpol.2009.11.008

Trisopon K, Kittipongpatana N, Kittipongpatana OS. A spray-dried, co-processed rice starch as a multifunctional excipient for direct compression. Pharmaceutics. 2020;12(6):1–18.

Trisopon K, Kittipongpatana OS. Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique. Starch/Staerke. 2019;71(5-6):1–8.

Kittipongpatana N, Janta S, Kittipongpatana O. Preparation of cross-linked carboxymethyl jackfruit starch and evaluation as a tablet disintegrant. Pak J Pharm Sci. 2011;24(4):415–20.

Zhang B, Dhital S, Haque E, Gidley MJ. Preparation and characterization of gelatinized granular starches from aqueous ethanol treatments. Carbohydr Polym [Internet]. 2012;90(4):1587–94. Available from: http://dx.doi.org/10.1016/j.carbpol.2012.07.035

Aulton, Michael E dan Taylor KM. Aulton’s Pharmaceutical The Design and Manufacture of Medicines 4th Edition. UK: Elsivier; 2013.

Dachriyanus. Analisis Struktur Senyawa Organik Secara Spektroskopi. Lembaga Pengembangan Teknologi Informasi dan Komunikasi (LPTIK); 2004.

Singh I, Sharma B, Arora G. Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starch-glycine conjugates as superdisintegrant. J Res Pharm. 2019;23(5):839–50.

Santosh Kumar R, Naga Satya Yagnesh T. Synthesis, characterization and evaluation of starch xanthate as a superdisintegrant in the formulation of fast dissolving tablets. Int J Appl Pharm. 2018;10(6):249–58.

Azubuike CP, Ubani-Ukoma UN, Afolabi AR, Cardoso-Daodu IM. Evaluation of super-disintegrant potential of acid-modified starch derived from Borassus aethiopum (Aracaceae) shoot in paracetamol tablet formulations. Trop J Pharm Res. 2020;19(3):459–65.

Desai PM, Liew CV, Heng PWS. Review of Disintegrants and the Disintegration Phenomena. J Pharm Sci [Internet]. 2016;105(9):2545–55. Available from: http://dx.doi.org/10.1016/j.xphs.2015.12.019

Desai PM, Er PXH, Liew CV, Heng PWS. Functionality of disintegrants and their mixtures in enabling fast disintegration of tablets by a quality by design approach. AAPS PharmSciTech. 2014;15(5):1093–104.

Brniak W, Jachowicz R, Pelka P. The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharm J [Internet]. 2015;23(4):437–43. Available from: http://dx.doi.org/10.1016/j.jsps.2015.01.015

Sharma D, Kumar D, Singh M, Singh G, Rathore MS. Fast Disintegrating Tablets: A New Era In Novel Drug Delivery System And New Market Opportunities. J Drug Deliv Ther [Internet]. 2012;2(3):74–86. Available from: http://www.irjponline.com/admin/php/uploads/1350_pdf.pdf

Chauhan K, Solanki R, Sharma S. A review on fast dissolving tablet. Int J Appl Pharm. 2018;10(6):1–7.

Lawal MV, Odeniyi MA, Itiola OA. Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol tablet formulations containing corn, cassava and sweet potato starches as filler-binders. Asian Pac J Trop Biomed [Internet]. 2015;5(7):585–90. Available from: http://dx.doi.org/10.1016/j.apjtb.2015.05.003

Odeku OA, Akinwande BL. Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches. Saudi Pharm J [Internet]. 2012;20(2):171–5. Available from: http://dx.doi.org/10.1016/j.jsps.2011.09.001

Rojas J, Buckner I, Kumar V. Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance. Drug Dev Ind Pharm. 2012;38(10):1159–70.

Mitrevej A, Sinchaipanid N, Faroongsarng D. Spray-dried rice starch: Comparative evaluation of direct compression fillers. Drug Dev Ind Pharm. 1996;22(7):587–94.

Kittipongpatana OS, Kittipongpatana N. Physicochemical, in vitro digestibility and functional properties of carboxymethyl rice starch cross-linked with epichlorohydrin. Food Chem [Internet]. 2013;141(2):1438–44. Available from: http://dx.doi.org/10.1016/j.foodchem.2013.04.030

Alam F, Hasnain A. Studies on swelling and solubility of modifi ed starch from taro (Colocasia esculenta): Effect of pH and temperature. Agric Conspec Sci. 2009;74(1):45–50.

Shojaee S, Nokhodchi A, Maniruzzaman M. Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets. Drug Deliv Transl Res [Internet]. 2017;7(1):111–24. Available from: http://dx.doi.org/10.1007/s13346-016-0344-5

Bashardoust N, Jenita JL, Zakeri-Milani P. Preparation and in vitro investigation of chitosan compressed tablets for colon targeting. Adv Pharm Bull. 2011;1(2):87–92.

Fukami J, Yonemochi E, Yoshihashi Y, Terada K. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int J Pharm. 2006;310(1-2):101–9.

Sonnergaard JM. Impact of particle density and initial volume on mathematical compression models. Eur J Pharm Sci. 2000;11(4):307–15.

Kittipongpatana OS, Sirithunyalug J, Laenger R. Preparation and physicochemical properties of sodium carboxymethyl mungbean starches. 2006;63:105–12.

Kittipongpatana OS, Chaitep W, Kittipongpatana N. Physicochemical and Pharmaceutical Properties of Cross-Linked Carboxymethyl Rice Starch Prepared by a Simultaneous Dual Reaction. 2010;214–20.

Wade A. dan Weller PJ. Handbook of Pharmaceutical Excipient. 6 th. London: The Pharmaceutical Press; 2009.

Anwar E, Djajadisastra J, Yanuar A, Bahtiar A. Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet Dan Niosom. Maj Ilmu Kefarmasian. 2004;1(1):34–46.

Kearsley MW dan Dziedzic SZ. Handbook of Starch Hydrolisis Products and Their Derivatives. London: Blackie Academy dan Professional; 1995.

Gonnissen Y, Remon JP, Vervaet C. Effect of maltodextrin and superdisintegrant in directly compressible powder mixtures prepared via co-spray drying. Eur J Pharm Biopharm. 2008;68(2):277–82.

Odeniyi MA yodel., Ayorinde JO. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. Polim Med. 2014;44(3):147–55.


Refbacks

  • There are currently no refbacks.


Copyright@ Pusat Penelitian Fakultas Farmasi

Universitas 17 Agustus 1945 Jakarta

Online ISSN : 2502-8421

 

Pengunjung