The research about the effectiveness of leaves of the soursop leaves (Annona muricata L.) extracts using three types of solvents e.g ethanol 70%, ethyl acetate and hexane in lowering total cholesterol blood level of white male mice induced with food high cholesterol (MLT) and prophyltiouracil for 21 days. The study was carried out experimentally by 8 groups, that are negative control group (normal), the positive control group (hypercholesterolemia), and treatment groups (given the test preparation) with dose of 100 mg/kgBB and 200 mg/kgBB. The observed parameter is total cholesterol blood levels of white male mice after 7 days administration of preparation. The results of statistical analyzed by one way ANOVA showed the ethanol 70%, ethyl acetate, and hexane extract of the leaves of soursop (Annona muricata.L) have significant differences between groups (p<0,05). Based on the percentage decrease of blood cholesterol levels, the ethyl acetate extract dose of 200 mg/kgBB is an extract of the most effective in lowering total blood cholesterol levels of male white mice.

 

Keywords : Blood Cholesterol Levels, Extract of Soursop Leaves, Propylthiouracil, MLT.

Anies. 2015. Kolesterol & Penyakit Jantung Koroner, Solusi Pencengahan dari Aspek Kesehatan Masyarakat. AR- Ruzz Media. Jogjakarta.

Aria, Mimi dan Arel, Afdil. 2014. Potensi Buah Rimbang (Solanium torvum Swartz) Sebagai Penurun Kadar Glukosa Dan Kolesterol Darah Tikus Diabetes. Prosiding Seminar Nasional dan Workshop “Perkembangan Terkini Sains Farmasi dan Klinik IV”. STIFI Perintis. Padang.

Djamal, R. 2010. Kimia Bahan Alam, Prinsip-prinsip Dasar Isolasi dan Identifikasi. Universitas Baiturrahmah. Padang.

Djuantoro, D. 2014. Buku Ajar Ilustrasi Patofisiologi, Edisi ke-4. Binarupa Aksara Publisher. Jakarta.

Guyton dan Hall. 2014. Buku Ajar Fisiologi Kedokteran, Edisi Kedua Belas. Jakarta.

Mardiana, Lina. 2013. Daun Ajaib Tumpas Penyakit. Swadaya. Jakarta.

Muhartono. Indri, W., Hendri, B., Hendra, TS dan Bayu Putra, DJ. 2014. Ekstrak Ethanol Daun Sirsak (Annona muricata L.) Berpotensi Memiliki Efek Kemoterapi Pada Kanker Payudara Tikus Putih. Jurnal Kedokteran Brawijaya, Universitas Lampung. Vol. 28, No. 1.

Murray, R.K., David A. Bender, Kathleen M. Botham, Peter J. Kennelly, Victor W. Rodwell,

P. Anthony Weil. 2014. Biokimia Harper, Edisi 29. Penerbit Buku Kedokteran EGC. Jakarta.

Purwatresna, E. 2012. Aktivitas Antidiabetes Ekstrak Air dan Etanol Daun Sirsak Secara In Vitro Melalui Inhibisi Enzim α- glukosidase. Skripsi Fakultas Matematika dan Ilmu Pengetahuan Alam. Institut Pertanian Bogor.

Tomkin, G. H. dan Owens, D. 2012. LDL As a Cause of Atherosclerosis. The Open Atherosclerosis & Thrombosis Journal, 5 13-12.

Uneputty, Jonly Pierre., Paulina V. Y., Yamlean dan Novel Stien Kojong. 2013. Potensi Infusa Daun Sirsak (Annona muricata L.) Terhadap Kadar Kolesterol Darah Tikus putih Jantan (Rattus novergius). Jurnal Ilmiah Farmasi Pharmachon- UNSRAT Vol. 2 No. 2.

Vogel, H. G. 2002. Drug Discovery and Evaluation Pharmacological Assay. Spinger. German.

Wulandari, R.L., Sri Susilowati dan Sucyati Amelya. 2015. Pengaruh Kombinasi Ekstrak Etanol Daun Sirsak dan Gemfibrozil Terhadap Kadar Trigliserida dan HDL Tikus Yang Diinduksi Pakan Tinggi Lemak. ISBN : 978-602-19556- 2-8.

Wurdianing, I., SA, Nugraheni dan Zen Rahfiludin. 2014. Efek Ekstrak Daun Sirsak (Annona muricata L.) Terhadap Profil Lipid Tikus Putih Jantan (Rattus Norvegicus). Jurnal Gizi Indonesia. Vol. 3, No. 1.