Amilase adalah hidrolase penting yang telah digunakan secara luas selama beberapa dekade. Enzim ini secara acak memotong ikatan glikosidik internal dalam molekul pati untuk menghidrolisisnya dan menghasilkan gula. Di antara amilase, α-amilase memiliki permintaan terbesar karena berbagai aplikasinya di bidang industri. Ketika konsumen menjadi lebih sadar akan masalah lingkungan, industri menemukan bahwa enzim dapat menggantikan katalis kimia lainnya. α-amilase dapat diproduksi dari tumbuhan atau sumber mikroba. Karena keuntungan yang diberikan oleh produksi mikroba, α-amilase dari mikroorganisme telah menjadi fokus perhatian dan lebih disukai daripada sumber produksi lainnya. Sifatnya yang ada di mana-mana, produksi yang mudah, dan berbagai aplikasi menjadikan α-amilase sebagai enzim yang penting bagi industri. Tujuan review ini adalah untuk memberikan informasi mengenai pengaplikasian enzim α-amilase yang berasal dari mikroba yaitu bakteri dan yeast serta pemanfaatannya dalam industri farmasi terutama dalam pembuatan maltodekstrin.

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